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Science

Evidence, as graded.

A five-level scale, a written rationale behind every grade, and a record that says where the evidence runs out.

The scale

Five levels, four in use. Counts from the 61 graded compound records; unreviewed foundation records show as insufficient and are not counted here.

  1. Strong

    Phase 3 randomized controlled trial data.

    14 of 61 compound records

  2. Moderate

    Human studies, at a smaller scale.

    12 of 61 compound records

  3. Limited

    Small human studies, or robust preclinical work.

    9 of 61 compound records

  4. Preliminary

    Animal or cell studies only.

    In the scale · not currently used

  5. Insufficient

    Inadequate evidence, or active safety concerns.

    26 of 61 compound records

Graded by use

Per application

28 of 61

records grade their uses differently.

Conflicting findings

6 records

list dissenting studies, kept on the record.

Human evidence

17 records

have no human studies on file. The grade says so.

Provenance

Version

Every record

A change is a new version, not a silent edit.

Last review

Dated

The date the evidence was last reviewed.

Review status

61 of 61 pending

Every compound record is currently pending review.

Uncertainty

No evidence is not evidence of no effect. An insufficient grade means the evidence isn’t there, or safety concerns outweigh it. RAEVOS doesn’t turn a missing answer into a negative one, or a positive one.

Boundaries

No dosing advice

RAEVOS doesn’t recommend a compound, a dose, a stack or a schedule.

A grade is not a safety rating

A strong grade describes the evidence for a use, not whether it is safe for you.

Private beta

Evidence, as it is.

RAEVOS is in private beta. Access opens in stages.

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